Sermorelin For Weight Loss: Everything You Need To Know

☑️ Scientific evidence-based article.
👨‍💼 Written by Abdur Rahman Choudhury, M.Sc., DN, CFT (Weight Loss Coach)
Published on
Updated on
Reading Time: 5 minutes

In this article, I will explain what sermorelin is and whether sermorelin helps you lose weight.

I will also explain the scientific meaning of losing weight and the best approach to weight loss.

Let’s dive in. 🧐

Growth Hormone
Sermorelin is a synthetic growth hormone-releasing hormone (GHRH). (Image source: Canva Pro)

About Sermorelin

Sermorelin is a synthetic (man-made) version of growth hormone-releasing hormone (GHRH). [1]

Your body produces GHRH hormone naturally from your pituitary gland. GHRH hormone stimulates the production of growth hormone (GH) from your pituitary gland into your bloodstream. [2]

In childhood, growth hormone (GH) primarily stimulates the growth of almost every tissue and organ in the body. [3]

But in adulthood, when you’ve finished growing, GH primarily helps to maintain normal body structure and regulate metabolism. [4]

The metabolic action of GH is to increase fat mobilization and oxidation, and thereby to reduce total body fat. It does that by stimulating lipolysis, a metabolic process through which triacylglycerols (TAGs) or triglycerides break down into glycerol and free fatty acids (FFAs). [5] [6]

Triacylglycerols are the form in which fat energy is stored in adipose tissue, and growth hormone helps release the energy by burning down the fat in adipose tissue. [7]

Studies indicate that this metabolic action of growth hormone is increased when you lower carbohydrate intake and during intermittent fasting. [8] [9]

That’s the simple explanation of sermorelin. 

Now, let me tell you what real weight loss is. 🤔

Fit women talking with overweight women
Weight loss is the process of reducing your total body weight. (Image source: Canva Pro)

About Weight Loss

Weight loss is the process of reducing your total body weight. [10]

Your body loses weight intentionally by following a healthy lifestyle, or unintentionally due to malnutrition or illness. [11]

The weight may come from fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue). [10]

You can find different solutions to lose weight. For example, diet and exercise, weight loss medication, and weight loss surgery.[12] 

When you’re trying to lose weight, it’s natural to want it to happen rapidly. But gradual and steady weight loss (about 1 to 2 pounds per week) is more natural and sustainable. [13] 

Achieving and maintaining a healthy weight is important for overall health and well-being. You need to consult a medical professional before starting any new diet or weight loss program.

Now, let’s come to the main topic of this article. 🧐

Sermorelin For Weight Loss
Sermorelin can be a great addition to your weight loss supplement stack, only if your doctor permits it. (Image source: Canva Pro)

Sermorelin For Weight Loss

In the previous section, I have explained what sermorelin is and its various functions.

Now the question is, 🤔

Does sermorelin help you lose weight?

Yes. Sermorelin helps you lose weight by stimulating human growth hormone, which increases fat mobilization and oxidation, in a low-carb diet. It is especially useful after 40 years of age, when your body can’t produce enough growth hormone. [5] [14]

That’s why older adults lose lean body mass and gain visceral/abdominal fat. [15] 

You may now think, 🤔

Do you need sermorelin to lose weight?

Sermorelin is especially useful for in older adults. Because their weight loss capacity is lower than young adults. In that case, sermorelin helps the pituitary gland to produce growth hormone to increase fat breakdown.

I highly recommend you not to use any hormonal supplements like sermorelin without doctor’s permission. It can increase or decrease the effects of prescription drugs. [16]

Ok. But, 🤔

Does sermorelin have any negative side effects?

Yes. Sermorelin has some side effects. The most common side effect of sermorelin is caused by its injection under your skin. The most common side effects are irritation, swelling, pain and redness. These reactions are typically short-lived and disappear without any action. 

Sermorelin may also interact with other medicines like levothyroxine, aspirin, prednisone, insulin, atropine, or levodopa. [17]

Now let’s end this topic.🙂

Weight Loss Word Cloud
Weight loss is easy with the right guidance and your hard work. (Image source: Canva Pro)


Sermorelin can be a great addition to your weight loss supplement stack, only if your doctor permits it. But don’t consider it as a magic pill.

First, fix your lifestyle. Because a healthy lifestyle is key to permanent weight loss. [13]

Furthermore, don’t follow any diet plans from an unauthentic source that claim quick weight loss. Because weight loss demand your hard work and dedication.

Also, everyone is different, and that’s why weight loss programs should be personalized.

▶️ To get a personalized weight loss program, visit here:

That’s it for now. If you want to read more informative weight loss articles, visit here: Weight Loss Blog. You can find more content about weight loss supplement here: Weight Loss Supplements.

Now ask me anything about weight loss in the comment section. I will reply as soon as I can.


This article is backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. 

You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Following are the references of this article.

  1. Mayo Clinic: Sermorelin (Injection Route) Description and Brand Names[]
  2. PubMed: Growth-hormone-releasing hormone[]
  3. You and Your Hormones from the Society for Endocrinology: Growth hormone[]
  4. Cleveland Clinic: HGH (Human Growth Hormone): What It Is, Benefits & Side Effects[]
  5. PubMed: Metabolic actions of growth hormone: direct and indirect[][]
  6. NCBI Bookshelf: Biochemistry, Lipolysis – StatPearls[]
  7. NCBI Bookshelf: The Role of Growth Hormone in Fat Mobilization – Designing Foods[]
  8. PubMed: Elevated insulin levels contribute to the reduced growth hormone (GH) response to GH-releasing hormone in obese subjects[]
  9. PubMed: Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man[]
  10. Wikipedia: Weight loss[][]
  11. Rxlist: Medical Definition of Weight loss[]
  12. NCBI Bookshelf: Weight-Loss and Maintenance Strategies – Weight Management[]
  13. CDC: Losing Weight | Healthy Weight, Nutrition, and Physical Activity[][]
  14. NCBI Bookshelf: Growth Hormone in Aging – Endotext[]
  15. PubMed: Age-related changes in growth hormone secretion: should the somatopause be treated?[]
  16. National Institute on Aging: Dietary Supplements for Older Adults[]
  17. Healthline: Sermorelin Therapy Benefits, Uses, Side Effects, Risks, More[]

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